What is the ICD-10 code for SIRS?

The ICD-10 codes for SIRS include R65.10 for non-infectious origin without organ dysfunction and R65.11 with organ dysfunction. For severe sepsis, use R65.20 or R65.21.

How do you code SIRS due to pancreatitis?

For SIRS due to pancreatitis, code the underlying condition (e.g., K85.9) first, followed by R65.10 if no organ dysfunction is present.

ICD-10 Coding for Systemic Inflammatory Response Syndrome(R65.10, R65.1, R65.11)

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Learn about ICD-10 coding for Systemic Inflammatory Response Syndrome (SIRS), including code ranges, documentation requirements, and common pitfalls.

Also known as:

SIRSsystemic response syndrome

Related ICD-10 Code Ranges

Complete code families applicable to Systemic Inflammatory Response Syndrome

R00-R99Primary Range

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

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Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

Code	Description	When to Use	Key Documentation
R65.10	Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction	Use when SIRS is diagnosed due to a non-infectious cause without organ dysfunction.	Temperature >38°C or <36°C Heart rate >90 beats/min Respiratory rate >20 breaths/min or PaCO2 <32 mmHg + 1 more
R65.11	Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction	Use when SIRS is diagnosed due to a non-infectious cause with organ dysfunction.	SIRS criteria plus evidence of organ dysfunction such as acute renal failure respiratory failure etc.
R65.20	Severe sepsis without septic shock	Use when severe sepsis is diagnosed without shock.	Sepsis criteria plus evidence of organ dysfunction without shock.
R65.21	Severe sepsis with septic shock	Use when severe sepsis is diagnosed with shock.	Sepsis criteria plus evidence of organ dysfunction and shock.

Primary ICD-10-CM Codes

Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

R65.10Billable

Differential Codes

Alternative codes to consider when ruling out similar conditions

SIRS of non-infectious origin with acute organ dysfunctionR65.11

SIRS of non-infectious origin without acute organ dysfunctionR65.10

Severe sepsis with septic shockR65.21

Severe sepsis without septic shockR65.20

Documentation & Coding Risks

Avoid these common issues when documenting Systemic Inflammatory Response Syndrome.

Failure to document organ dysfunction when present.

Impact

Clinical: Inaccurate representation of patient severity., Regulatory: Non-compliance with coding guidelines., Financial: Potential loss of reimbursement.

Mitigation

Ensure thorough documentation of all clinical findings., Use templates to guide documentation.

Coding SIRS as the principal diagnosis when an underlying condition is present.

Impact

Reimbursement: Incorrect sequencing can lead to denied claims., Compliance: Non-compliance with ICD-10-CM guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation

Always code the underlying condition first.

Confusing SIRS with sepsis.

Impact

Reimbursement: Incorrect coding affects DRG assignment., Compliance: Potential audit issues., Data Quality: Misrepresentation of patient condition.

Mitigation

Ensure documentation specifies non-infectious vs. infectious causes.

Incorrect sequencing of SIRS codes

Impact

Coding SIRS as principal diagnosis instead of underlying condition.

Mitigation

Educate coders on proper sequencing rules.

Frequently Asked Questions

Documentation requirements, coding pitfalls and FAQs for conditions coded with R65.10.

Primary Code

R65.10

Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

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ICD-10 codes6

Coding risks4

FAQs2

ICD-10 Coding for Systemic Inflammatory Response Syndrome(R65.10, R65.1, R65.11)

Documentation & Coding Risks

Frequently Asked Questions

What is the ICD-10 code for SIRS?

How do you code SIRS due to pancreatitis?

Related condition guides