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C49Non-billableSave

C49 - Malignant neoplasm of other connective and soft tissue

ICD-10-CM Chapter 2: Neoplasms · C45-C49 Malignant neoplasms of mesothelial and soft tissue (C45-C49) · Top-level category · FY2027

Coding Guidance

C49 is a non-billable heading. Report one of the 10 more specific codes below.

Includes, Excludes and Coding Notes

IncludesFrom C49

Conditions this code covers.

  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)
Excludes 1 — Not Coded HereFrom C49

Mutually exclusive: these conditions are never reported together with this code.

  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)
Excludes 2 — Not Included HereFrom C49

Not part of this code; report both codes when the patient has both conditions.

  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)
NotesFrom Chapter C00-D49

Instructional notes from the ICD-10-CM tabular list.

  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

More Specific Codes (10)

C49.0Malignant neoplasm of connective and soft tissue of head, face and neck→C49.1Malignant neoplasm of connective and soft tissue of upper limb, including shoulder→C49.2Malignant neoplasm of connective and soft tissue of lower limb, including hip→C49.3Malignant neoplasm of connective and soft tissue of thorax→C49.4Malignant neoplasm of connective and soft tissue of abdomen→C49.5Malignant neoplasm of connective and soft tissue of pelvis→C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified→C49.8Malignant neoplasm of overlapping sites of connective and soft tissue→C49.9Malignant neoplasm of connective and soft tissue, unspecified→C49.AGastrointestinal stromal tumor→

Related condition guides

Documentation requirements, coding pitfalls and FAQs for conditions coded with C49.