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D89.835BillableSave

D89.835 - Cytokine release syndrome, grade 5

ICD-10-CM Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism · D80-D89 Certain disorders involving the immune mechanism (D80-D89) · Subcategory of D89.83 · FY2027

Includes, Excludes and Coding Notes

Use Additional CodeFrom D89.83

Add a secondary code to identify the associated condition or cause when it is documented.

  • code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
  • code to identify associated manifestations
Code FirstFrom D89.83

Sequence the underlying condition before this code.

  • underlying cause, such as:
  • complications following infusion, transfusion and therapeutic injection (T80.89-)
  • complications of transplanted organs and tissue (T86.-)
Excludes 1 — Not Coded HereFrom D89

Mutually exclusive: these conditions are never reported together with this code.

  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes 2 — Not Included HereFrom D89

Not part of this code; report both codes when the patient has both conditions.

  • transplant failure and rejection (T86.-)
IncludesFrom D80-D89 Certain disorders involving the immune mechanism (D80-D89)

Conditions this code covers.

  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis
Excludes 1 — Not Coded HereFrom D80-D89 Certain disorders involving the immune mechanism (D80-D89)

Mutually exclusive: these conditions are never reported together with this code.

  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)
Excludes 2 — Not Included HereFrom D80-D89 Certain disorders involving the immune mechanism (D80-D89)

Not part of this code; report both codes when the patient has both conditions.

  • human immunodeficiency virus [HIV] disease (B20)
Excludes 2 — Not Included HereFrom Chapter D50-D89

Not part of this code; report both codes when the patient has both conditions.

  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Related condition guides

Documentation requirements, coding pitfalls and FAQs for conditions coded with D89.835.