D82Non-billableSave
D82 - Immunodeficiency associated with other major defects
ICD-10-CM Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism · D80-D89 Certain disorders involving the immune mechanism (D80-D89) · Top-level category · FY2027
Coding Guidance
D82 is a non-billable heading. Report one of the 7 more specific codes below.
Includes, Excludes and Coding Notes
Excludes 1 — Not Coded HereFrom D82
Mutually exclusive: these conditions are never reported together with this code.
- ataxia telangiectasia [Louis-Bar] (G11.3)
IncludesFrom D80-D89 Certain disorders involving the immune mechanism (D80-D89)
Conditions this code covers.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes 1 — Not Coded HereFrom D80-D89 Certain disorders involving the immune mechanism (D80-D89)
Mutually exclusive: these conditions are never reported together with this code.
- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71-)
Excludes 2 — Not Included HereFrom D80-D89 Certain disorders involving the immune mechanism (D80-D89)
Not part of this code; report both codes when the patient has both conditions.
- human immunodeficiency virus [HIV] disease (B20)
Excludes 2 — Not Included HereFrom Chapter D50-D89
Not part of this code; report both codes when the patient has both conditions.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
More Specific Codes (7)
D82.0Wiskott-Aldrich syndromeBillable→D82.1Di George's syndromeBillable→D82.2Immunodeficiency with short-limbed statureBillable→D82.3Immunodeficiency following hereditary defective response to Epstein-Barr virusBillable→D82.4Hyperimmunoglobulin E [IgE] syndromeBillable→D82.8Immunodeficiency associated with other specified major defectsBillable→D82.9Immunodeficiency associated with major defect, unspecifiedBillable→
Chapter Information
Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Range: D50-D89
View full chapterRelated ICD-10 Codes
More specific codes for D82
Wiskott-Aldrich syndrome
D82.0›
Di George's syndromeD82.1›
Immunodeficiency with short-limbed statureD82.2›
Immunodeficiency following hereditary defective response to Epstein-Barr virusD82.3›
Hyperimmunoglobulin E [IgE] syndromeD82.4›
Immunodeficiency associated with other specified major defectsD82.8›
Immunodeficiency associated with major defect, unspecifiedD82.9›
Other categories in this chapter
Codes at the same level as D82
- Iron deficiency anemiaD50
- Vitamin B12 deficiency anemiaD51
- Folate deficiency anemiaD52
- Other nutritional anemiasD53
- Anemia due to enzyme disordersD55
- ThalassemiaD56
- Sickle-cell disordersD57
- Other hereditary hemolytic anemiasD58
- Acquired hemolytic anemiaD59
- Acquired pure red cell aplasia [erythroblastopenia]D60
- Other aplastic anemias and other bone marrow failure syndromesD61
- Acute posthemorrhagic anemiaD62
- Anemia in chronic diseases classified elsewhereD63
- Other anemiasD64
- Disseminated intravascular coagulation [defibrination syndrome]D65
- Hereditary factor VIII deficiencyD66
- Hereditary factor IX deficiencyD67
- Other coagulation defectsD68
- Purpura and other hemorrhagic conditionsD69
- NeutropeniaD70
- Functional disorders of polymorphonuclear neutrophilsD71
- Other disorders of white blood cellsD72
- Diseases of spleenD73
- MethemoglobinemiaD74
- Other and unspecified diseases of blood and blood-forming organsD75
- Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissueD76
- Other disorders of blood and blood-forming organs in diseases classified elsewhereD77
- Intraoperative and postprocedural complications of the spleenD78
- Immunodeficiency with predominantly antibody defectsD80
- Combined immunodeficienciesD81
- Common variable immunodeficiencyD83
- Other immunodeficienciesD84
- SarcoidosisD86
- Other disorders involving the immune mechanism, not elsewhere classifiedD89